Recognition of Lipid Antigens by Cd1d-Restricted Type-2 NKT Cells

Grant number: 1083885 | Funding period: 2015 - 2017

Completed

Abstract

Protection against infection depends on T cells, which recognise and target foreign molecules called antigens via a specialized antigen receptor known as a T cell receptor (TCR). This project focuses on a specialised population of T cells called Natural Killer T (NKT) cells that recognise lipid antigens. The work outlined in this grant will increase our understanding of how different TCRs can recognise diverse lipid antigens thus providing insight into the role of NKT cells in the immune system.

Related publications (3)

Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d

CF Almeida, DGM Smith, TY Cheng, CM Harpur, E Batleska, CV Nguyen-Robertson, T Nguyen, T Thelemann, SJJ Reddiex, S Li, SBG Eckle, I van Rhijn, J Rossjohn, AP Uldrich, DB Moody, SJ Williams, DG Pellicci, DI Godfrey

2021-08-24

Natural killer T (NKT) cells detect lipids presented by CD1d. Most studies focus on type I NKT cells that express semi-invariant α..

Unappreciated diversity within the pool of CD1d-restricted T cells

DG Pellicci, AP Uldrich

2018-12-01

Studies of lipid reactive CD1d-restricted T cells have focussed on α-galactosylceramide reactive semi-invariant Type I NKT cells, ..

Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens

J Le Nours, T Praveena, DG Pellicci, NA Gherardin, FJ Ross, RT Lim, GS Besra, S Keshipeddy, SK Richardson, AR Howell, S Gras, DI Godfrey, J Rossjohn, AP Uldrich

2016-02-15

Crucial to Natural Killer T (NKT) cell function is the interaction between their T-cell receptor (TCR) and CD1d-antigen complex. H..

University of Melbourne Researchers

Daniel Pellicci